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pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Might produce lack of virologic reaction and achievable resistance.pentobarbital will reduce the level or impact of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabo